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Drug and Chemical Toxicology Volume 13, 1990 - Issue 4
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Research Article

Partitioning of Oxamniquine into Brain Tissue Following Intravenous Administration to Female Wistar Rats

Gilbert O. Kokwaro Welsh School of Parmacy, University of Wales College of Cardiff, P.O. Box 13, Cardiff, CF1 3XF, Great Britain
&
Glyn Taylor Welsh School of Parmacy, University of Wales College of Cardiff, P.O. Box 13, Cardiff, CF1 3XF, Great Britain
Pages 347-354 | Published online: 27 Sep 2008
 
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ABSTRACT

Brain and plasma concentrations of oxamniquine were determined following intravenous dosing (15 mg kg1) in female Wistar rats. Maximum brain concentrations were achieved one hour after dosing and at all sampling times oxamniquine levels were higher in brain tissues compared to the corresponding plasma samples.

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