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Abstract
Cathecolamines have an important role in the regulation of LH secretion. The effect of two selective blocking drugs of cathecolamines synthesis upon pituitary response to LH-RH was studied. Basal levels of serum LH in rats treated with a-methyl-p-tyrosine and diethyldithiocar-bamate were significantly lower than those of control rats. Diethyldithiocarbamate induced a greater decrease of LH levels than α-methyl-p-tyrosine. The rats treated with diethyldithiocarbamate showed an LH increase after LH-RH stimulation that was significantly higher as compared with control group as well as in α-methyl-p-tyrosine treated group.