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Abstract
Digestion of human sperm chromatin with micrococcal nuclease reveals an 160 base pair (b.p.) DNA fragment that is further degraded to a series of DNA fragments remarkably similar to the micrococcal nuclease digestion products of eukaryote somatic cellular chromatin. DNase I digestion of human sperm chromatin also yields an identical pattern of DNA fragments to that observed upon DNase I digestion of somatic chromatin. These data, together with earlier electron microscopic observations, suggest a nucleosomal structure for human sperm chromatin.