Variant D and G-Chromosomes in Male-Related Infertility

Abstract

Cytogenetic studies were performed on normal and infertile men using R-banding technique and Ag-staining for NORs, In sterile subjects, minor chromosomal abnormalities (enlarged or double satellites, enlarged short arms of acrocesrtics, secondary constriction with elongation) were found more frequently than in fertile men. The most frequently involved chromosomes were 15, 21, and 22. Positive correlation existed between the frequency of acrocentric variants and sterility, due to an increase of risk satellite association and of nondisjunction leading to aneuploidy in gametes.

Key Words:

• Male infertility
• Satellites
• NORs
• Variants (polymorphisms)
• D and G group chromosomes