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Abstract
Pyruvate dehydrogenase activity in the mitochondrial fraction obtained from Arbacia punctulata sperm was inhibited by 76%, 40%, and 8% at gossypol concentrations of 50, 20, and 10 μM, respectively. Activities of Mg2+- and Na+, K+-dependent ATPases from sperm mitochondria of Hemicentrotus pulcherrius were also inhibited proportionally to the concentrations of gossypol, ranging from 10 to 80 μM. Gossypol inhibits the activities of pyruvate dehydrogenase complex and Na+, K+- and Mg2+-dependent ATPases of sea urchin spermatozoa, thereby influencing mitochondrial function and flagellar movement.