Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

R. C. Martin-du-pan Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

P. Bischof Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

B. Bourrit Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

K. Lauber Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

J. P. Girard Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

W. L. Herrmann Department of Obstetrics and Gynaecology and Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Genève, Switzerland

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) and inhibition of phytohemagglutinin (PHA)-induced lymphocyte transformation were measured in 51 seminal plasma samples obtained from oligozoospermic (n = 22), normospermic (n = 22), and vasectomized men (n = 7). In nonvasectomized men, PAPP-A significantly correlated with the percentage inhibition of lymphocyte transformation. The possibility of PAPP-A being an immunosuppressive principle of human seminal plasma is discussed.

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Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

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Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

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