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Abstract
Production of 4-androstene-7α, 17β-diol-3-one (7α-hydroxytestosterone) from testosterone was measured in seminiferous tubule and interstitial fractions of rat testis. In adults, specific activity of the 7α-hydroxylase was about 10 times higher in interstitial cells than in seminiferous tubules, but tubule production was a significant portion of the total. Seminiferous tubule 7α-hydroxylase was not detectable in weanlings. Also, we confirmed that 7α-hydroxytestosterone inhibits the activity of the 5α-reductase and 3α-hydroxysteroid dehydrogenase active on testosterone and suggest a role in maturational changes.