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Abstract
Hemiorchidectomized rats were followed up to 15 days postsurgery for morphologic evaluation of compensatory testicular response and its correlation to serum testosterone levels. Although gross compensatory testicular hypertrophy (CTH) was not noted, an enlarged interstitium was observed with hypertrophy and hyperplasia of Leydig cells with morphologic changes suggestive of increased cellular activity. These histologic changes were accompanied by compensatory testicular hypersecretion (CTHS) illustrated by the return of the serum testosterone levels to near the intact-control value in the later groups. Ultrastructural studies of the Leydig cells indicated an increase in the amount of smooth endoplasmic reticulum as an underlying mechanism for this response. In view of the previously reported normal serum luteinizing hormone levels after hemicastration, the compensatory hyperactivity/ hypersecretion should be considered primarily an intrinsic Leydig cell response, not related to changes in the hypothalamo-hypophyseal axis.