Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 24, 1990 - Issue 1
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Original Article

Modulation of Lipid Peroxidation in Human Spermatozoa and Human Prostate by Prostatic Inhibin

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Pages 29-34 | Received 11 Jul 1989, Published online: 09 Jul 2009
 

Abstract

Loss of sperm motility as a result of the production of hydrogen peroxide by lipid peroxidation is regulated by as yet unidentified prostatic factor(s). Inhibinlike peptide of prostatic origin isolated from human seminal plasma, with a molecular size of about 10,400 daltons, was studied for its effect on ascorbate-induced lipid peroxidation in human spermatozoa. Dose-related suppression of lipid peroxidation was observed at dose levels of 0.25, 0.5, and 1.0 μg. The data suggest that inhibinlike peptide could be one of the factors involved in the regulation of lipid peroxidation and thereby of sperm motility. Inhibinlike peptide also exhibited local action in both normal and benign hyperplastic human prostate tissue by enhancing the rate of lipid peroxidation. These findings have implications in the pathophysiology of the prostate.

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