The Importance of the Hypoosmotic Swelling Test and Acrosin Activity Assay for Identifying Subpopulations of Idiopathic Infertile Men

T. Toda Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

N. Sofikitis Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

I. Miyagawa Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

P. Zavos Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

T. Harada Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

Y. Mio Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

N. Terakawa Departments of Ob/Gyn and Urology, Tottori University School of Medicine, Yonago, Japan; Department of Animal Science, University of Kentuckyand the Andrology Institute of Lexington, Lexington, KY, USA

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Abstract

Semen samples collected from fertile donors (n - 13) and pooled samples from idiopathic infertile men (n = 19) were used in this study. Measurements of the total sperm acrosin activity and the hypoosmotic swelling test (HOST) were performed in all the samples. The percentage of swollen spermatozoa and acrosin profiles were significantly lower in the infertile men than in the fertile donors. Considering the lowest values of the outcome of the HOST and the acrosin activity assay in the group of fertile men as the lowest normal values, it was proven that HOST and acrosin activity assay could identify subpopulations of infertile men of 37 and 26%, respectively. The results tend to support the employment of the HOST and the acrosin activity assay in the evaluation of idiopathic infertile men.

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The Importance of the Hypoosmotic Swelling Test and Acrosin Activity Assay for Identifying Subpopulations of Idiopathic Infertile Men

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The Importance of the Hypoosmotic Swelling Test and Acrosin Activity Assay for Identifying Subpopulations of Idiopathic Infertile Men

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