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Abstract
Semen samples (n = 40) obtained from males attending an infertility clinic were subjected to bacteriological culture and categorized as bacteriologically negative (group I) and bacteriologically positive (group II) depending on the culture positivity. Semen samples from both groups were simultaneously analyzed for routine parameters such as volume, count, motility, viability, morphology, pH, and hypoosmotic swelling. Seminal plasma was assayed for levels of prolactin (PRL), prolactin-suppressing factor (PSF), prostatic inhibin peptide (PIP) and zinc (Zn). Patients in group II (n = 25) showed statistically significant alteration (p <. 01) in semen parameters such as motility, percent normal morphological forms, and percent normal HOS test as compared to group I (n = 15). There was a negligible change in the sperm concentration between the two groups. The semen volume, viability, and pH did not show any variation. Among the regulatory factors assayed, there was a significant change in the Zn, PSF (p <. 05), and PIP (p -. 01), while no such alterations were seen for PRL. The results suggest that bacterial infection affects fertility either by affecting the seminal characteristics directly or by acting on the regulatory systems.