Profile of Ocular and Adnexal Tumours at a Tertiary Institute of Northeast India

Abstract

Purpose: To present the profile of patients with ocular and adnexal tumours presenting at a tertiary eye care institute in northeast India in ten years between 2003 and 2013.

Design: Hospital based retrospective review of medical records.

Method: The clinical history, site of involvement and pathological diagnoses were retrieved from ocular pathology registers from October 2003-October 2013. This included conjunctival, orbital, adnexal and intraocular tumours. All specimens were fixed, processed and stained. Immunohistochemistry was carried out where ever indicated to come to a final diagnosis.

Results: In all 1003 cases were included in our study, with 622 (62.01%) benign tumours and 381 (37.98%) malignant tumours. 54.63% were males and 45.36% were females. Amongst the conjunctival tumours, squamous cell carcinoma (SCC) (72.5%) and nevus (39.6%) were the most common malignant and benign tumour, respectively. Non-Hodgkin’s lymphoma (NHL) (60%) was the most common malignant orbital tumour. Retinoblastoma (RB) (81.5%) was the most common intraocular malignancy, followed by melanoma (18.4%). Basal cell carcinoma (BCC) (35.1%) was the most common malignancy in the lid.

Conclusion: NHL and SCC were the most frequently seen malignant tumours in adults while RB was the most common intraocular tumour in children.

• Non-Hodgkin’s lymphoma
• retinoblastoma
• tumours
• squamous cell carcinoma

Acknowledgments

We are thankful to Mr. Akshay Chandra Deka, our former laboratory technician, Mr. Nayanmoni Das for data related work as well as the radiologists and oncologists (Dr. BBCI, Guwahati, India).

We also feel indebted to Dr. Jagannath Dev Sarma, HOD, Pathology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, India; Prof. Saidul Islam, Parasitologist, Department of Parasitology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India; Dr. Jyotirmay Biswas and Dr. S Krishnakumar from Ocular Pathology Department, Sankara Nethralaya, Chennai, India for their help and guidance.

We also wish to express our gratitude to Indian Council of Medical Research and Sri Kanchi Sankara Health and Educational Foundation for the study.