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Journal of Neurogenetics Volume 1, 1984 - Issue 2
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Original Article

Pedigree Study of Familial Alzheimer Disease

Diane Powell Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
&
Marshal F. Folstein Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Pages 189-197 | Received 04 Mar 1983, Accepted 15 Aug 1983, Published online: 11 Jul 2009
 
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Abstract

Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

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