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Ultrastructural Pathology Volume 5, 1983 - Issue 2-3
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Original Article

Signet-Ring Cell Variant of Large Cell Lymphoma

I. Dardick Canadian Tumour Reference Centre, Clinical Studies Unit Building, Ottawa, K1Y 4M9, Canada; Department of Pathology, Salvation Army Grace General Hospital, Ottawa, Canada
,
R. Srinivasan Canadian Tumour Reference Centre, Clinical Studies Unit Building, Ottawa, K1Y 4M9, Canada; Department of Pathology, Salvation Army Grace General Hospital, Ottawa, Canada
&
M. Al-Jabi Canadian Tumour Reference Centre, Clinical Studies Unit Building, Ottawa, K1Y 4M9, Canada; Department of Pathology, Salvation Army Grace General Hospital, Ottawa, Canada
Pages 195-200 | Accepted 28 Mar 1983, Published online: 10 Jul 2009
 
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Abstract

A diffuse, large cell lymphoma of palatine tonsil was found to contain a considerable number of enlarged tumor cells with prominent, hyaline, Russell body-type cytoplasmic inclusions displacing the nucleus peripherally and, thus, the morphologic features of signet-ring cell lymphoma. Immunoperoxidase staining revealed that the contents of the signet-ring cells were strongly positive for μ heavy chains and κ light chains. Ultrastructurally, Russell body-type inclusions consisted of multiple, angulated, electron-dense crystalloids enclosed within expanded segments of rough endoplasmic reticulum.

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