Low Magnification Transmission Electron Microscopy in Diagnostic Pathology

Peter Rippstein Department of Laboratory Medicine, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada; Department of Pathology, University of Ottawa, Ottawa, Ontario, Canada

Sharon Cavell Department of Laboratory Medicine, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada; Department of Pathology, University of Ottawa, Ottawa, Ontario, Canada

Marie Boivin Department of Laboratory Medicine, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada; Department of Pathology, University of Ottawa, Ottawa, Ontario, Canada

Irving Dardick Department of Laboratory Medicine, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada; Department of Pathology, University of Ottawa, Ottawa, Ontario, Canada

Abstract

Transmission electron microscopy examination of selected diagnostic specimens, that is, renal and nerve biopsies, can be greatly facilitated by the implementation of slot grid preparations that are inherently devoid of any grid bars. Such preparations are conducive to screening and photography at both low and intermediate modes of magnification without any apparent loss of resolution. The use of this technique in diagnostic electron microscopy is simplified by sequential en bloc staining with both uranyl and lead salts.

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Low Magnification Transmission Electron Microscopy in Diagnostic Pathology

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Low Magnification Transmission Electron Microscopy in Diagnostic Pathology

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