Assessment of Anthracycline Cardiomyopathy by Endomyocardial Biopsy

Bruce Mackay Departments of Pathology, Medical Specialties, Diagnostic Radiology, and Medical Oncology, University of Texas MD. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

Michael S. Ewer Departments of Pathology, Medical Specialties, Diagnostic Radiology, and Medical Oncology, University of Texas MD. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

C. Humberto Carrasco Departments of Pathology, Medical Specialties, Diagnostic Radiology, and Medical Oncology, University of Texas MD. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

Robert S. Benjamin Departments of Pathology, Medical Specialties, Diagnostic Radiology, and Medical Oncology, University of Texas MD. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

Abstract

Ultrastructural evaluation of endomyocardial biopsy specimens is a sensitive and effective method with which to detect and quantitate cardiotoxicity produced by anthracylines. The procedure and grading system used at the M.D. Anderson Cancer Center are described, and some of the pitfalls that may be encountered by the electron microscopist are reviewed.

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Assessment of Anthracycline Cardiomyopathy by Endomyocardial Biopsy

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Assessment of Anthracycline Cardiomyopathy by Endomyocardial Biopsy

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