Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

Quazi T. H. ShubhraDoctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungaryCorrespondence[email protected]

Andrea F. KardosResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary

Tivadar FeczkóResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary

Hana MackovaInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 16206 Prague 6Czech Republic

Daniel HorákInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 16206 Prague 6Czech Republic

Judit TóthResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary

György DósaDepartment of Mathematics, Faculty of Information Technology, University of Pannonia Veszprém, Egyetem u. 10Hungary

János GyenisResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary

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Abstract

PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA® software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS™/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329 nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion energy (enough sonication time) along with small aqueous/organic volume ratio.

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Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

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Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

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