Abstract
Using a 500 kHz radiofrequency electromagnetic heating system, the effects of localized current field hyperthermia in normal rabbit eyes were examined. A specially designed scleral plaque placed on normal rabbit eyes was heated to temperatures of 43°C, 45°C, and 47°C for a period of 45 min. The effects of hyperthermia were monitored by clinical examination, fluorescein angiography, electroretinography and histopathology. A graded effect with increasing temperature was found at the lower temperature, and it was confined to the treatment field. At 47CC the electroretinogram was extinguished due to diffuse photoreceptor damage outside the treatment field, as demonstrated by histo-pathology and electron microscopy. This study indicates that hyperthermia at 45°C for 45 min is me maximum allowable temperature without causing diffuse retinal damage in the normal rabbit eye.
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