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Abstract
Heat treatment at 30°C for 15 min immediately after ultraviolet (UV) irradiation enhanced cell killing of Dictyostelium discoideum. However, when the cells were UV-irradiated and cultured at 23°C for 30 min before giving UV irradiation and heat treatment, the enhancement of cell killing by heat treatment immediately after post-UV irradiation was depressed. Similar depressions in the heat enhancement of cell killing of UV-irradiated cells were also observed in the case of the cells cultured after pre-treatment with 4-nitroquinoline 1-oxide, cis-platinum(II) diaminedichloride or 8-methoxypsoralen photoaddition, but not with N-methyl-iV′-nitro-N′-nitrosoguamdine or methylmethanesulphonate. These results suggest that the depression in heat enhancement in cell killing of UV-irradiated cells may be deeply related with kinds of DNA lesions or DNA repair processes for them.