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Abstract
The effects of hyperthermal stress on the coagulation and fibrinolytic systems were examined in five healthy subjects who took a 3-min 47d`C hotspring bath. After a 3-min 47d`C bath, the sublingual temperature was transiently increased about 1.8d`C, returning to the baseline level within 60min. The plasma level of plasmino-gen activator inhibitor-1 antigen (PAI-1) was transiently increased 15 min after the start of bathing and returned to the pre-bathing level 360 min later. The plasma levels of tissue plasminogen activator antigen, al plasmin inhibitor activity, plasmin-antiplasmin complex, thrombin-antithrombin III complex, and thrombo-modulin antigen were not influenced by the bath. The in vivo result correlated well with the in vitro result that PAI-1 was released from cultured endothelial cells by heating. These findings suggest that the increase in plasma PAI-1 level may be due to the direct hyperthermal action of the very hot hotspring bath on the endothelial cells and that acute hyperthermal stress may decrease the fibrinolytic capacity, leading to the occurrence of thrombotic events.