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Abstract
The changes in the blood flow in SCC-VII tumours after step-down and stepup heating (SDH and SUH) were compared. SDH was carried out by initial treatment of tumours in a water bath at 44.5d`C for lOmin, immediately followed by heating at 41.5d`C for 60min. For SUH, the sequence of these high- and lowtemperature treatments was reversed. Tumour perfusion was evaluated by laser Doppler flowmetry (LDF) at 1, 2, and 24 h after finishing the hyperthermia. It was shown that the decrease in the blood flow in tumours was more substantial after SDH than after SUH; in the former case, the drop in LDF values was both faster and larger than in the latter. It is concluded that such a ‘physiological’ component may be involved in the difference in the antitumour effect between SDH and SUH.