Isolated cranio-spinal involvement of Rosai-Dorfman disease: case report

Abstract

Rosai-Dorfman disease is a rare non-neoplastic lymphoproliferative condition. It commonly affects individuals between third and fifth decades, most common presentation being in the form of massive painless cervical lymphadenopathy with fever, weight loss and malaise. Isolated intracranial involvement is rare seen in less than 5% of patients with extranodal involvement. We present a patient with isolated contiguous cranio-spinal involvement who presented to us with remitting symptoms.

Key words:

• Rosai–Dorfman disease
• emperipolesis
• S-100 protein
• CD-68 antigen

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.