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Original Article

The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex

, , , , , , & show all
Pages 701-706 | Received 28 May 2010, Accepted 17 Aug 2010, Published online: 28 Sep 2010
 

Abstract

Object. We investigated the protective effects of avocado/soybean unsaponifiables (ASU) on the prefrontal cortex (PFC) after global brain ischemia/reperfusion (I/R) injury in rats.

Methods. Rats were randomly divided into three experimental groups as follows: Group I was control rats, Group II was ischemia rats, Group III was Isch + ASU rats. Brain ischemia was produced via four-vessel occlusion model. These processes followed by reperfusion for 30 min for both II and III groups. Rats were sacrificed and their brains were removed immediately. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in left PFC, levels of TNF-α concentration were measured in the plasma. The number of apoptotic neurons was assayed in histological samples of the right PFC.

Results. MDA and TNF-α levels as well as the number of apoptotic neurons were observed to have decreased significantly in Group III compared to Group II, while SOD activities have been found to have increased significantly in Group III in comparison to Group II, significantly.

Conclusions. We think that ASU might have an antioxidant and neuroprotective effects in brain I/R injured rats.

Acknowledgements

This study was supported by the Kocatepe University Scientific Research Committee (Project no. 051.TIP.14). The authors alone are responsible for the content and writing of the paper.

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