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Abstract
Paraffin sections of 305 meningeal tumours were analysed for the presence of nucleolar organizer region (Ag-NOR) in the neoplastic cells, using a one step silver-colloidal staining method. The mean (± SEM) Ag-NOR counts were 2.73 ± 0.21 for atypical and 2.91 ± 0.18 for papillary variants of meningioma. In meningothelioma-tous and transitional variants of meningioma, the mean Ag-NOR counts were 1.41 ± 0.34 and 1.38 ±0.31, respectively. The recurrence rates were significantly higher in atypical meningiomas than in other histopatholog-ical variants (p<0.05). Differences in the mean Ag-NOR numbers between meningothelial and transitional variants in their primary and recurrent tumours were not significantly different (p < 0.05). The results of this study indicates that estimation of Ag-NORs can be applied in predicting the aggressive clinical behaviour of primary meningeal tumours.