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Abstract
Purpose: The basic objective of this study is to develop the Flurbiprofen sodium soluble ocusert to increase patient compliance by improving local delivery of the drug.
Materials and Methods: Three different polymers were used in combination to prepare the rate controlling membrane. The drug reservoir was prepared by using hydroxy propyl methyl cellulose. Ocuserts were evaluated for their physicochemical parameters. The optimized formulations were further evaluated for accelerated stability studies, eye irritancy tests, and for in vivo drug release studies.
Results: Ocuserts were found stable at room temperature and showed a strong positive correlation between in vitro and in vivo drug release.
Conclusion: An appropriate combination of hydrophilic and hydrophobic polymers provides better control of drug delivery.
ACKNOWLEDGMENTS
The authors are highly grateful to FDC Ltd. (Mumbai, India) for providing the sample of the drug and to Colorcon Asia Pvt. Ltd. (Goa, India) and Ozone International (Mumbai, India) for providing the polymers.
DECLARATION OF INTEREST
The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.