Birth weight and asthma incidence by asthma phenotype pattern in a racially diverse cohort followed through adolescence

Abstract

Objective: Low birth weight (LBW) has been shown to be an independent risk factor for asthma. We hypothesized that LBW would have its greatest impact on early onset disease. Methods: A racially diverse cohort of children born from 1983 to 1985 at two hospitals, one urban and one suburban in the same metropolitan area, and oversampled for babies weighing ≤2500 g, was identified retrospectively when the children were 6 years of age and followed periodically. At the age 17 years study visit, cohort members and their parent/guardians were separately interviewed face-to-face regarding the subject’s history of asthma using the standardized ISAAC questionnaire. We measured the cumulative incidence of asthma from birth through adolescence defined by age of diagnosis and persistence/remittance. Results: Six-hundred and eighty teens (82.6% of the original cohort) were included in the analyses, 387 with LBW and 293 of normal birth weight. The prevalence of physician-diagnosed “Current Asthma” was associated with LBW (p = 0.003 for trend), with patterns stronger in males and whites. LBW was associated most strongly with Late Onset Persistent asthma (current asthma that was diagnosed after 8 years); p for trend 0.032. This trend was again most evident in males and whites. None of the asthma categories classified as “remittent” were statistically associated with LBW. Conclusions: LBW was not associated with diagnosed asthma that remitted before age 17 years. LBW was associated with asthma diagnosis in mid-childhood that persisted through adolescence, suggesting that the asthmagenic effects of LBW can become evident post the early years of childhood and persist into adulthood.

• Age of onset
• blacks
• cumulative incidence
• ISAAC
• life course epidemiology
• pediatrics
• whites

Declaration of interest

This study has been funded by US National Institutes of Health (MH44586) (AI24156) (AI50681) (HL068971) (AI089473); Fund for Henry Ford Hospital. The authors have no conflict of interest. The authors alone are responsible for the content and writing of this paper.

Supplementary material available online

Supplementary material Tables S1 and S2.