Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese

Abstract

Objective: RAD50-IL13 region has been recently identified as one of critical asthma susceptibility loci in genome-wide association studies, yet the role of these genetic variants or single-nucleotide polymorphisms (SNPs) in the risk of developing asthma in Northeastern Han Chinese remains largely unknown. Methods: We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. Results: We did not find the allele or genotype frequency distribution of four SNPs in RAD50-IL13 region which was significantly different between asthmatic children and controls (p > 0.05). Conclusions: Our findings first suggested that the variants in RAD50-IL13 region were not associated with asthma risk in Northeastern Han Chinese children.

• Asthma
• Han Chinese children
• RAD50
• IL13
• single-nucleotide polymorphism

Declaration of interest

The authors declare no conflict of interest and have received no payment in preparation of this manuscript. This work was sponsored by the Natural Science Foundation of Heilongjiang Province (D201204).