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Abstract
House dust contains allergens which are both soluble and insoluble in aqueous solutions. The water-soluble allergens differ depending on the two methods of extraction used. The water-insoluble allergens can be removed by a solvent such as DMSO or Dimethylsulfoxide.
Diagnosis of sensitivity to the water-insoluble DMSO fraction of crude house dust was made by provocative sublingual testing. Therapy was by periodic direct application of the DMSO extract to the skin. Tests were made on 645 patients with 113 positive reactors. Forty of these reactors had previous therapy with Endo, Center, or both dusts but still had some degree of symptomatology. All 40 improved to some degree when the DMSO dust was added to therapy.
This method of extraction and the product obtained is new and has proven to be an important missing link in the field of house dust allergy.