Abstract
Purpose: To investigate the acute renal effects of 2 osmolality levels of iomeprol in a double-blind, randomized, parallel-group study.
Material and Methods: Ten patients received iomeprol 300 mg I/ml, and a further 10 received iomeprol 400 mg I/ml intraarterially at routine abdominal angiography. the mean volume of contrast medium administered was 227.3±59.3 ml in the iomeprol 300 group and 221.5±30.9 ml in the iomeprol 400 group.
Results: the urinary minute volume increased immediately after angiography, but tended to return to baseline 120 min after the examination. No significant decrease in creatinine clearance occurred; however, the fraction excretion of sodium increased immediately after angiography. the lysosomal enzyme N-acetyl-β-glucosaminidase and the proximal tubular brush border enzyme γ-glutamyl transferase increased up to 120 min after the procedure. Free water clearance was negative during each study period. No statistical differences in any parameter were evident between these 2 groups.
Conclusion: These results suggest that osmotic diuresis and its acute effect on proximal tubular function are induced by the administration of iomeprol, but that these changes are reversible.