Primary Irradiation, Surgery or Combined Therapy in Squamous Cell Carcinoma of the Larynx: A comparison of treatment results from two centers

H. Vermund Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

M. Boysen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

J. H. Brandenburg Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

J. Evensen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

A.-B. Jacobsen Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

O. Kaalhus Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

J. Tausjø Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

E. Thorud Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

A. L. Wiley Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

F. Winther Department of Biophysics and Research Institute, Norwegian Radium Hospital, Oslo, Norway; Departments of Otolaryngology and Radiation Oncology, The Norwegian Radium and National Hospital, Oslo, Norway; Departments of Otolaryngology and Human Oncology, Section of Radiation Oncology, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

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Abstract

We compared two groups of patients with squamous cell carcinoma of the larynx. Group 1 consisted of 483 patients treated from 1958 through 1978. Primary surgery was selected in 41%, pre- or postoperative radiation therapy in 16% and primary radiation therapy in 43%. Group 2 consisted of 247 patients treated from 1978 through 1983. Primary surgery was selected in only 1.6%, pre- or postoperative radiation therapy in 23%, and primary radiation therapy, with surgery in reserve for residual or recurrent carcinoma, in 76%. Although the results were comparable for patients with early stage tumors in the two groups, significantly higher local-regional tumor control rates and corrected survival rates were recorded for patients with advanced tumors in group 2. More patients survived with a cancer-free functional larynx, the surgical salvage rates were higher, the complication rates and the death rates lower in group 2 compared to group 1.

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Primary Irradiation, Surgery or Combined Therapy in Squamous Cell Carcinoma of the Larynx: A comparison of treatment results from two centers

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Primary Irradiation, Surgery or Combined Therapy in Squamous Cell Carcinoma of the Larynx: A comparison of treatment results from two centers

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