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Abstract
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.
Acknowledgements
The Northern UK Study thanks all study interviewers, administrators, computer programmers and the study Steering Group chaired by Professor David Coggon, along with the many neuropathologists, neuroradiologists, neurosurgeons, neurooncologists, clinical oncologists, neurologists, nurses and administrators in Scotland, West Midlands and West Yorkshire. The Swedish centre was supported by the Swedish Research Council, the Cancer Foundation of Northern Sweden, the Swedish Cancer Society, and the Nordic Cancer Union and the Umeå University Hospital Excellence grant. The Danish centre was supported by the Danish Cancer Society. Beatrice Melin was supported from Acta Oncologica foundation through the Royal Swedish Academy of Science. The cases were identified through the INTERPHONE study and supported by the European Commission Fifth Framework Program “Quality of life and Management of Living Resources” (contract number QLK4-CT-1999-01563) and the International Union against Cancer (UICC). The UICC received funds for this purpose from the Mobile Manufacturers’ Forum and GSM Association. Provision of funds to the INTERPHONE study investigators via the UICC was governed by agreements that guaranteed INTERPHONE's complete scientific independence. These agreements are publicly available at http://www.iarc.fr/ENG/Units/RCAd.html. The Northern UK Study centre received funding from the Mobile Telecommunications and Health Programme, the Health and Safety Executive, the Department of Health, the Scottish Executive, and the United Kingdom Network Operators (‘‘O2’’, Orange, T-Mobile, Vodafone, ‘‘3’’). The authors have no conflict of interest to declare.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.