Abstract
Numerous randomised clinical trials have shown that the efficacy of single fraction radiotherapy for metastatic bone pain corresponds to that of multiple fractions of radiotherapy for the majority of patients. It is not clear to which extent single fraction radiotherapy has been implemented into clinical practice. Material and methods. A Norwegian national registry-based study was conducted, including all radiotherapy schedules of 8 Gy × 1 and 3 Gy × 10 delivered to bone metastases in 1997–2007. Binomial regression analyses were used to study whether treatment centre, primary diagnosis, anatomical region irradiated, age, sex, and travel distance, were associated with the choice of fractionation. Results. A total of 14 380 radiotherapy episodes were identified. During the period 31% of the treatments were delivered as 8 Gy × 1. The proportion of single fraction treatments increased from 16% in 1997 to 41% in 2007. There were substantial differences in the proportion of single fraction treatments between the treatment centres (range 25–54%). These differences persisted after adjustment for sex, age, primary diagnosis, anatomical region, and travel distance. Conclusions. The study demonstrates an underutilisation of single fraction treatment for bone metastases in Norway during the study period.
Acknowledgements
We thank Olaug Talleraas for assistance in extracting data from the Cancer Registry of Norway. We thank Oslo University Hospital, The Norwegian Radium Hospital; St. Olavs Hospital, University Hospital of Trondheim; Oslo University Hospital, Ullevål; University Hospital of North Norway, Tromsø; Stavanger University Hospital; Haukeland University Hospital, Bergen; Ålesund Hospital; Nordland Hospital, Bodø; Innlandet Hospital Trust, Gjøvik; and Sørlandet Hospital Kristiansand, for entering data to the Cancer Registry of Norway. The project was funded by the Faculty of Medicine at the Norwegian University of Technology and Science in Trondheim, Norway.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.