Pharmacokinetics of Intravenously Administered Desmosine in Sheep

Pritam S. Verma Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, 20307

Robert F. Hoyt Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, 20307

Andre J. Jackson School of Pharmacy, University of Maryland, Baltimore, MD, 21201

Yancy Y. Phillips Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, 20307

Abstract

The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t1/2 β) of desmosine varied between 81–489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is via the kidney.

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Pharmacokinetics of Intravenously Administered Desmosine in Sheep

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Pharmacokinetics of Intravenously Administered Desmosine in Sheep

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