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Abstract
Collagen fibril diameters were measured in molar and incisor periodontal ligaments of adult rats given aminoacetonitrile (0.15% in their drinking water). Fibrils were also measured in the periodontal ligaments of pair-fed control animals and animals fed ad libitum. The lathyrogen produced a significant change in the distribution of fibril diameters in both molars and incisors and an increase in mean fibril diameter in incisors relative to pair-fed controls. The reduced food intake of the pair-fed control group produced a significant decrease in mean fibril diameter in incisors relative to the ad libitum control group. These results suggest that lathyrogens may affect collagen fibril diameters in an adult connective tissue in a manner similar to that previously shown for a fetal tissue.