Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth

T. K. Gray Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC; Departments of Medicine, Pediatrics and PhysiologyLoma Linda, University and Pettis V.A. Hospital, Loma, Linda, CA

B. Lipes Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC; Departments of Medicine, Pediatrics and PhysiologyLoma Linda, University and Pettis V.A. Hospital, Loma, Linda, CA

T. Linkhart Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC; Departments of Medicine, Pediatrics and PhysiologyLoma Linda, University and Pettis V.A. Hospital, Loma, Linda, CA

S. Mohan Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC; Departments of Medicine, Pediatrics and PhysiologyLoma Linda, University and Pettis V.A. Hospital, Loma, Linda, CA

D. Baylink Departments of Medicine and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC; Departments of Medicine, Pediatrics and PhysiologyLoma Linda, University and Pettis V.A. Hospital, Loma, Linda, CA

Abstract

A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.

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Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth

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Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth

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