Hormonal Regulation of Coliagen Gene Expression in Osteoblastic Cells-Overview and New Findings

Barbara Kream Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

John Harrison Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

Robert Bailey Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

Donna Petersen Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

David Rowe Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

Alexander Lichtler Departments of Medicine and Pediatrics, University of Connecticut Health Center, Farmington, CT

Abstract

Type I collagen synthesis in osteoblasts is regulated by a variety of systemic hormones, growth factors and locally produced factors. With the use of cDNA probes and hybridization analysis, it appears that many of these agents alter collagen synthesis by a pretranslational mechanism.

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Hormonal Regulation of Coliagen Gene Expression in Osteoblastic Cells-Overview and New Findings

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Hormonal Regulation of Coliagen Gene Expression in Osteoblastic Cells-Overview and New Findings

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