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Abstract
The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in normal embryonic development, cellular differentiation, and response to tissue damage. Not surprisingly, as it is a multi-faceted regulatory system, numerous pathological conditions are associated with aberrant activity of the PDGFs and their receptors. As we and others have shown, human gliomas, especially glioblastoma, express all PDGF ligands and both the two cell surface receptors, PDGFR-α and -β. The cellular distribution of these proteins in tumors indicates that glial tumor cells are stimulated via PDGF/PDGFR-α autocrine and paracrine loops, while tumor vessels are stimulated via the PDGFR-β. Here we summarize the initial discoveries on the role of PDGF and PDGF receptors in gliomas and provide a brief overview of what is known in this field.
Acknowledgements
We acknowledge the financial support from the Swedish Cancer Society, the Swedish Childhood Cancer Foundation, the Swedish Research Council, the Cancer Society in Stockholm, and the King Gustaf V Jubilee Fund. We also acknowledge the support from Karolinska Institutet and the Stockholm County Council, to the core facilities Mouse Tissue Analysis (MTA) and Karolinska Healthcare Research Biobank (KHRBB). This review is partly based on the thesis summary of Inga Nazarenko (ISBN 978-91-7457-451-7).
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.