Cyclosporin A Treatment in a Case of Relapsing Polychondritis

K. L. G. Svenson Department of Internal Medicine, Uppsala university, Uppsala, Sweden

R. Holmdahl Department of Immunology, Uppsala university, Uppsala, Sweden

L. Klareskog Department of Immunology, Uppsala university, Uppsala, Sweden

L. Wibell Department of Internal Medicine, Uppsala university, Uppsala, Sweden

O. Sjöberg Department of Clinical Immunology, Uppsala university, Uppsala, Sweden

G. B. G. Klintmalm Division of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden

H. Boström Department of Internal Medicine, Uppsala university, Uppsala, Sweden

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Abstract

A patient with relapsing polychondritis and high titres of anti-collagen II antibodies developed a progressive destruction of tracheal cartilage in spite of treatment with corticosteroids, Dapsone, Azathioprine and cyclophosphamide. Assumptions regarding the role of anti-collagen immunity, together with immunohistochemical studies on affected cartilage, suggested macrophage-T cell interactions to be important in the pathogenesis of the disease. Cyclosporin A treatment was instituted and has been continued for 2 years, concomitant with a steady improvement and remission of the disease.

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Cyclosporin A Treatment in a Case of Relapsing Polychondritis

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Cyclosporin A Treatment in a Case of Relapsing Polychondritis

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