Lack of Effect of Tranexamic Acid on Rheumatoid Arthritis

G. G. Rasmussen Department of Rheumatology, Odense University Hospital, Denmark

I. Brandslund Institute of Medical Microbiology, Odense University Hospital, Denmark; Department of Clinical Chemistry, Odense University Hospital, Denmark

P. Urfe Department of Rheumatology, Aalborg Hospital, Denmark

B. Teisner Institute of Medical Microbiology, Odense University Hospital, Denmark

H. C. Siersted Institute of Medical Microbiology, Odense University Hospital, Denmark

P. Hindersson Institute of Medical Microbiology, Odense University Hospital, Denmark

H. I. Lund Department of Rheumatology, Odense University Hospital, Denmark

E. F. Nielsen Department of Rheumatology, Aalborg Hospital, Denmark

E. Arfelt Department of Rheumatology, Odense University Hospital, Denmark

A. Jensen Department of Rheumatology, Odense University Hospital, Denmark

J. Dalsgaard Department of Rheumatology, Odense University Hospital, Denmark

S.-E. Svehag Institute of Medical Microbiology, Odense University Hospital, Denmark

J. Dyerberg Department of Clinical Chemistry, Aalborg Hospital, Denmark

G. Nymand Department of Clinical Immunology, Søderborg Hospital, Denmark

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Abstract

In a double-blind controlled study on 45 rheumatoid arthritis patients, no effect of tranexamic acid (Cyklocapron®, 4.5 g per day for 6 weeks) was found in terms of subjective or objective parameters of disease activity. Tranexamic acid did not reduce complement activation, measured by plasma concentrations of the complement C3 split product C3d. Immune complex concentrations in serum were also unaffected. We conclude that plasmin inhibitors do not reduce immune complex mediated complement activation, and they should not be used for treatment of rheumatoid arthritis.

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Lack of Effect of Tranexamic Acid on Rheumatoid Arthritis

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Lack of Effect of Tranexamic Acid on Rheumatoid Arthritis

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