Outcome of Systemic Lupus Erythematosus a Study of 66 Patients over 7 Years with Special Reference to the Predictive Value of Anti-DNA Antibody Determinations

Abstract

Gripenberg, M. and Helve, T. Outcome of Systemic Lupus Erythematosus. A Study of 66 Patients over 7 Years with Special Reference to the Predictive Value of Anti-DNA Antibody Determinations. Scand J Rheumatol 1991; 20: 104-109.

A cohort of 66 patients with SLE that were thoroughly studied, both clinically and serologically in 1980-81, when they had a mean disease duration of eight years, were evaluated seven years later in order to assess the long-range outcome of the disease. Five patients were lost from follow-up and 12 (20%) died during the follow-up. The estimated 10-year survival was 91%. A total of 30 patients (45%), showed no signs of nephritis at any stage, and in only eight an active nephritis was found during the follow-up. The previous antibody determinations, provided no predictive information regarding the behaviour of the renal manifestations. Arthralgia was the main clinical symptom during the follow-up. Hypertension developed in 23%. At the end of the follow-up the disease was regarded as active in 13% of the patients.

Key Words:

• SLE
• follow-up
• survival
• anti-DNA antibodies