Subsets of Activated T Cells in Patients with Systemic Lupus Erythematosus: the Relation to Cell Cycle

Y. Tokano Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

S. Morimoto Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

T. Hishikawa Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

A. Murashima Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

M. Abe Department of Pathology, Juntendo University, Tokyo, Japan

I. Sekigawa Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

Y. Takasaki Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

H. Hashimoto Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

K. Okumura Department of Immunology, Juntendo University, Tokyo, Japan

T. Shirai Department of Pathology, Juntendo University, Tokyo, Japan

S. Hirose Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan

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Abstract

The correlation among the various markers of activated T cells (soluble interleukin 2 receptor (sIL-2R). HLA-DR⁺ and HLA-DP′ T cells, proliferating cell nuclear antigen (PCNA) positive lymphocytes) were examined in patients with systemic lupus erythematosus (SLE), and related to the cell cycle. The concentration of slL-2R and the proportion of HLA-DR⁺ T cells. HLA-DP⁺ T cells or PCNA⁺ lymphocytes were increased significantly as compared to that in normal subjects. And, the concentrations of sIL-2R correlated with the proportions of PCNA⁺ lymphocytes, but not with the proportions of HLA-DR⁺ T cells, HLA-DP⁺ T cells. The correlation between sIL-2R and PCNA⁺ lymphocytes was attributed to both indicators being increased during the GIB or S phase in normal T cells upon stimulation by phytohemagglutinin (PHA). Upon cell cycle analysis it was learned that activated T cells could be found in the Gl A and the S phases.

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Subsets of Activated T Cells in Patients with Systemic Lupus Erythematosus: the Relation to Cell Cycle

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Subsets of Activated T Cells in Patients with Systemic Lupus Erythematosus: the Relation to Cell Cycle

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