Charcot Knee Arthropathy with Articular Amyloid Deposition in Familial Amyloidotic Polyneuropathy

M. Shiraishi Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Kumamoto, Japan

Y. Ando First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

H. Mizuta Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Kumamoto, Japan

E. Nakamura Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Kumamoto, Japan

K. Takagi Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Kumamoto, Japan

M. Ando First Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

Abstract

An extremely rare case of familial amyloidotic polyneuropathy (FAP) complicated by neuroarthropathy (Charcot joint) in the left knee joint and by intra-articular deposits of amyloid was observed. FAP-specific variant transthyretin (TTR) was found in the synovial fluid and amyloid deposits were confirmed in the synovium, cartilage and bone by Congo red staining and immuno-staining.

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Charcot Knee Arthropathy with Articular Amyloid Deposition in Familial Amyloidotic Polyneuropathy

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Charcot Knee Arthropathy with Articular Amyloid Deposition in Familial Amyloidotic Polyneuropathy

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