Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome

Abstract

Background and aims: Metabolic syndrome (MetS) is an insulin-resistance syndrome deeply associated with obesity. The association between MetS and several clinical factors, including serum levels of adiponectin, C-reactive protein and insulin, was examined.

Subjects and methods: The study was performed in 219 men aged 43.2 ± 6.6 years, who were employees of a company. The study measured the serum high sensitivity C-reactive protein (CRP) as an inflammatory marker, serum insulin as a marker of insulin resistance and serum high-molecular-weight adiponectin (HMW-adipo), in addition to the serum levels of liver enzymes and uric acid. MetS was diagnosed according to the National Cholesterol Education Programme ATPIII criteria.

Results: Log-transformed serum ALT, HMW-adipo, insulin and uric acid were found to be significantly related to the presence/absence of Mets by logistic regression analysis, with odds ratios (95% confidence intervals) of 25.9 (3.3–204.4), 0.10 (0.02–0.56), 7.5 (1.6–34.1) and 1.5 (1.04–2.1), respectively.

Conclusion: Serum high HMW-adipo level was significantly negatively related to the presence of MetS, independently of the serum levels of insulin, liver enzymes and uric acid. Among the markers examined, serum HMW-adipo and ALT were considered as markers for MetS.

Keywords::

• High-molecular-weight adiponectin
• metabolic syndrome
• insulin
• C-reactive protein
• liver enzymes

Acknowledgements

We wish to express our appreciation to the study participants. This work was supported by Grant-in-Aid for Scientific Research (C) (20590616) and partly by Smoking Research Foundation.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.