Identification of a New α Chain Variant at Codons 22–25 (–9 nts) Using the Sebia Capillarys 2 Electrophoresis System

Can Liao Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China

Jian-Ying Zhou Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China

Xing-Mei Xie Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China

Ying-Na Liu Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China

Li-He Chen Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China

Dong-Zhi Li Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of ChinaCorrespondence[email protected]

Abstract

We have identified a new α chain hemoglobin (Hb) variant in a Chinese family. Sequencing of the amplified α2-globin gene revealed a 9 nucleotide (nt) deletion (–C GAG TAT GG) at codons 22–25, which results in a predicted α-globin chain that is missing amino acid residues 23–25 (Glu-Tyr-Gly) and the formation of Hb Zhanjiang.

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Identification of a New α Chain Variant at Codons 22–25 (–9 nts) Using the Sebia Capillarys 2 Electrophoresis System

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Identification of a New α Chain Variant at Codons 22–25 (–9 nts) Using the Sebia Capillarys 2 Electrophoresis System

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