Relationship between critical relative humidity and solubility of drugs

Yingli WangKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Xiancheng ZhanKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. ChinaCorrespondence[email protected]

Lin LuoKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Jia ChenKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Chaoqun XiangKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Chengrong LiKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Linli LiKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China

show all

Abstract

Both the critical relative humidity (H_cr) and the solubility are important physicochemical properties that affect the quality of drugs. However, the relationship between them is not noticed yet. By an analysis of interaction between molecules of drug and water, the conclusion logically obtained is: the higher the solubility is, the lower the H_cr will be. To validate this idea, the H_cr and the solubility of 33 drugs and chemicals were determined and a negative linear correlation was found between the two factors when the solubility was expressed as the mole fraction of water. This negative linear correlation was further confirmed by a computer simulation according to modified Debye-Hückel equation.

Keywords::

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Relationship between critical relative humidity and solubility of drugs

Information for

Open access

Opportunities

Help and information

Relationship between critical relative humidity and solubility of drugs

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature