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Research Article

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

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Pages 270-279 | Received 02 Oct 2014, Accepted 25 Apr 2015, Published online: 02 Jun 2015
 

Abstract

In this work, aqueous diltiazem HCl and polyvinyl-pyrrolidone (PVP) solutions were mixed with Kollicoat SR 30D and spray dried to microparticles of different drug:excipient ratio and PVP content. Co-spray dried products and physical mixtures of drug, Kollidon SR and PVP were tableted. Spray drying process, co-spray dried products and compressibility/compactability of co-spray dried and physical mixtures, as well as drug release and water uptake of matrix-tablets was evaluated. Simple power equation fitted drug release and water uptake (R2 > 0.909 and 0.938, respectively) and correlations between them were examined. Co-spray dried products with PVP content lower than in physical mixtures result in slower release, while at equal PVP content (19 and 29% w/w of excipient) in similar release (f2 > 50). Increase of PVP content increases release rate and co-spray drying might be an alternative, when physical mixing is inadequate. Co-spray dried products show better compressibility/compatibility but higher stickiness to the die-wall compared to physical mixtures. SEM observations and comparison of release and swelling showed that distribution of tableted component affects only the swelling, while PVP content for both co-spray dried and physical mixes is major reason for release alterations and an aid for drug release control.

Acknowledgements

The authors would like to thank Dr. Iyad Rashid and Dr. Adnan Badwan (Jordanian Pharmaceutical Manufacturing Company, Amman, Jordan) for the facilitation and help with the use of Gamlen bench top press. The authors dedicate this paper to Professor Bassam Tashtoush who prematurely passed away during revision of the manuscript.

Declaration of interest

The authors report no conflicts of interest.

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