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Abstract
Brominated perfluorocarbon compounds are a new and unique type of contrast agents. These compounds are biologically inert and chemically stable. Highly concentrated (8:l to 10:l by volume) oil in water emulsions have been found to be stable and non-irritating and useful in bronchography in humans and animals and in angiography in animal studies. The physical properties of these unusual emulsions have been investigated. The emulsiona have non-Newtonian properties, low interfacial tensioas and a broad distribution of particle size.
The emulsion, as well as the pure compounds, has been the subject of an IND application with the Food and Drug Administration. The investigations on the use of the emulsion in bronchography and the pure compounds in alveolography md gastroen-terography are on going and are in Phase II of the IND.