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Abstract
The effect of particle size distribution on the dissolution of salicylic acid in an automated dissolution apparatus has been studied. Tablets were prepared by individually weighing 200 mg of the drug particles having a narrow size distribution, compressing the tablets using a hydraulic press and employing identical compression force for the same time period for each tablet. The results showed that the range values obtained were not significantly different from those obtained when the particle size was not controlled. However, the range values obtained from the dissolution of drug particles recovered from the tablet formulation were found to be similar to the range values obtained from the dissolution of the tablet formulation, indicating that compression during tabletting was responsible for observed differences.