Tie Effect of Disintegrants and Processing on the Bioavailability of Frusemide from Compressed Tabllts

Abstract

Batches of frusemide tablets were produced using Explotab, polyplasdone XL, Amberlite IRP88, maize atarch, and Elcesan P100 as disintegrants. Bioavailability atudies were carried out on a double blind basis.

The bioavailability differences between formulations was shown to be significant. Explotab rendered the fruseulide far more bioevailable than the other four disintegrants.