Effect of Processing Factors on the Qualities of Reserpine Tablets

Abstract

Reserpine tablets were made by five different processing techniques. The tablets were tested for weight variation, content uniformity, hardness, friability and disintegration. The stability of reserpine in the com-pressed tablets was evaluated at accelerated conditions of 50° and 83% R. H. for a period of 6 months and at room conditions for 18 months. In-vitro availability studies were conducted on the tablets produced by the various techniques. It is shown that the method of preparation of tablets influences their properties in cluding stability and in-vitro availability.